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ORIGINAL ARTICLE
Year : 2020  |  Volume : 3  |  Issue : 2  |  Page : 75-79

A retrospective analysis of 128 patients of primary intracranial tumors treated at a tertiary cancer center in Nashik, Maharashtra


Department of Radiation Oncology, Shri Guruji Rugnalaya, Nashik, Maharashtra, India

Correspondence Address:
Dr. Girish Bedre
Babasaheb Ambedkar Vaidyakiya Pratisthan's, Shri Guruji Rugnalaya, Gangapur Road, Nashik - 422 005, Maharashtra
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/IJNO.IJNO_11_20

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Background: Brain tumors are a heterogeneous group of neoplasms. They are classified into various subgroups depending on the cell of origin and their molecular signature in the 2016 WHO classification. Their incidence is very low. Males are most commonly affected than females and have bimodal age peak. Headache and vomiting are the most common presenting symptoms followed by seizures. The best imaging modality for accurate diagnosis is Magnetic Resonance Imaging (MRI) with contrast along with various other sequences. In almost all CNS tumours, maximal safe resection is the primary treatment. Accurate histopathological diagnosis with molecular markers helps in planning adjuvant therapy and prognostication. Materials and Methods: This is a retrospective analysis of 128 patients of primary intracranial tumours treated at a private tertiary cancer centre during September 2014 to February 2020. In this analysis, we have analysed the data with respect to various factors like age at diagnosis, sex ratio, symptomatology, location of tumours, imaging modality, surgical details and histopathological diagnosis. Results: In our analysis, we found maximum cases in 5th decade of life. Overall, males were most commonly affected than females (1.5 :1). Convulsion was the most common presenting symptom. MRI was done in 91.5% cases for initial diagnosis. The most common histology was glioblastoma multiforme and 116/ 128 patients underwent surgery as the primary treatment. Immunohistochemistry & molecular testing was done in only 30 patients. Radiotherapy with or without chemotherapy was offered to most of the cases and 61.9% patients were treated with IMRT or VMAT. Conclusion: To our knowledge, this is the first report with large patient cohort from a private non academic institution and represents a real world day to day scenario. The distribution of cases with respect to age, male to female ratio, commonest pathological subtype were found to be consistent with the available literature except the presenting symptom. There is a need of improved pathological & radiological reporting.


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