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ORIGINAL ARTICLE
Year : 2020  |  Volume : 3  |  Issue : 1  |  Page : 26-31

Bioinformatics analysis of SOX2 gene expression in gliogenesis


School of Life Sciences; Department of Biotechnology; Department of Life Science and Bioinformatics, Assam University, Silchar, Assam, India

Correspondence Address:
Mr. Shouhartha Choudhury
School of Life Sciences, Assam University, Silchar - 788 011, Assam; Department of Biotechnology, Assam University, Silchar - 788 011, Assam; Department of Life Science and Bioinformatics, Assam University, Silchar - 788 011, Assam
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/IJNO.IJNO_4_20

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Background: Glioblastoma is the most aggressive cerebral tumor is invariable and lethal. The previous stem cell experiment reported the glioblastoma is expressed in neural cells. SOX2 gene has self-renewal ability in the neural stem cells. The SOX2 gene is a master regulator involved in sustaining self-renewal in neural stem cells. Therefore, the study of the SOX2 gene is essential to explore the aberrant growth of glioblastoma. The SOX family characterized by the DNA-binding domain (high-mobility group [HMG] domain) is involved in the developmental process in mammals. Objective: The present study objective was to investigate the SOX family in mammals. The SOX family plays an essential role during the developmental process in mammals. Therefore, the investigation of the SOX family in the mammalian genome is now mandatory to explore the specific function of the SOX2 gene. Methods: In this study, the author performed powerful bioinformatics and computational technique to the current knowledge of the SOX family in particular organisms. Results: The present study findings confirmed the presence of SOX2 gene in both organisms. The author took a closer look at the SOX family and analyzed genes known so far those that have a different functional domain. The findings provide evidence of the SOX family and their HMG domain in between Homo sapiens and Mus musculus. The conserved domain, motifs, phylogeny, Chromosome location, and gene expression hypothesized that the SOX2 gene is expressed in neural stem cells. Conclusion: The findings concluded that the SOX family is associated with the developmental process in mammals. In contrast, the SOX2 gene expression controls the proliferation of neural stem cells. The downregulated expression of SOX2 gene leads to the loss of tumorigenicity. These observations support the hierarchical model of glioblastoma controlled by SOX2 gene, which would be the ultimate target for glioblastoma therapy.


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