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  Indian J Med Microbiol
 

Figure 2: (a) Glioma Stem Cells in therapy resistance: Glioma Stem Cells show increased efflux of drugs due to enhanced expression of drug transporters like ABCG2 resulting in chemoresistance. Increased expression of DNA repair enzymes like O6-methylguanine DNA methyltransferase results in radioresistance. (b) Applications of extracellular vesicles in glioblastoma diagnosis: Glioma cells and glioma-derived extracellular vesicles can cross the blood–brain barrier and enter the circulation where they serve as potential circulatory biomarkers. Tumor cell DNA in circulation is also found to carry specific mutations present in parent glioma cells

Figure 2: (a) Glioma Stem Cells in therapy resistance: Glioma Stem Cells show increased efflux of drugs due to enhanced expression of drug transporters like ABCG2 resulting in chemoresistance. Increased expression of DNA repair enzymes like O6-methylguanine DNA methyltransferase results in radioresistance. (b) Applications of extracellular vesicles in glioblastoma diagnosis: Glioma cells and glioma-derived extracellular vesicles can cross the blood–brain barrier and enter the circulation where they serve as potential circulatory biomarkers. Tumor cell DNA in circulation is also found to carry specific mutations present in parent glioma cells